Biblio

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2020
Mukenge S, Jha SK, Catena M, Manara E, Leppänen V‐M, Lenti E, et al.. Investigation on the role of biallelic variants in VEGF‐C found in a patient affected by Milroy‐like lymphedema. Molecular Genetics & Genomic Medicine [Internet]. 2020;00:e1389. https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389PDF icon Mukenge et al. 2020 (1.06 MB)
Mukenge S, Jha SK, Catena M, Manara E, Leppänen V‐M, Lenti E, et al.. Investigation on the role of biallelic variants in VEGF‐C found in a patient affected by Milroy‐like lymphedema. Molecular Genetics & Genomic Medicine [Internet]. 2020;00:e1389. https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389PDF icon Mukenge et al. 2020 (1.06 MB)
Gucciardo E, Lehti TA, Korhonen A, Salvén P, Lehti K, Jeltsch M, et al.. Lymphatics and the eye. [Finnish]. Duodecim Lääketieteellinen Aikakauskirja [Internet]. 2020;136(16):1777-1788. https://www.duodecimlehti.fi/lehti/2020/16/duo15739PDF icon Gucciardo et al. Lymphatics and the Eye (English version). (3.31 MB)
Gucciardo E, Lehti TA, Korhonen A, Salvén P, Lehti K, Jeltsch M, et al.. Lymphatics and the eye. [Finnish]. Duodecim Lääketieteellinen Aikakauskirja [Internet]. 2020;136(16):1777-1788. https://www.duodecimlehti.fi/lehti/2020/16/duo15739PDF icon Gucciardo et al. Lymphatics and the Eye (English version). (3.31 MB)
Gucciardo E, Lehti TA, Korhonen A, Salvén P, Lehti K, Jeltsch M, et al.. Lymphatics and the eye. [Finnish]. Duodecim Lääketieteellinen Aikakauskirja [Internet]. 2020;136(16):1777-1788. https://www.duodecimlehti.fi/lehti/2020/16/duo15739PDF icon Gucciardo et al. Lymphatics and the Eye (English version). (3.31 MB)
Fang S, Chen S, Nurmi H, Leppänen V-M, Jeltsch M, Scadden DT, et al.. VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche. Blood [Internet]. 2020;:accepted - for publication. https://ashpublications.org/blood/article/doi/10.1182/blood.2020005699/463465/VEGF-C-Protects-the-Integrity-of-Bone-MarrowPDF icon Fang et al. 2020 - VEGF-C protects the integrity of bone marrow perivascular niche (6 MB)
2019
Lackner M, Schmotz C, Jeltsch M. The Proteolytic Activation of Vascular Endothelial Growth Factor-C. Lymphologie in Forschung und Praxis [Internet]. 2019;23(2):88 - 98. https://doi.org/10.5281/zenodo.3629263PDF icon English version: Lackner et al. 2019 (2.94 MB)PDF icon German version: Lackner et al. 2019 (673.37 KB)
2017
Jha SK, Rauniyar K, Kärpänen T, Leppänen V-M, Brouillard P, Vikkula M, et al.. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Scientific Reports [Internet]. 2017;7(1):4916. https://www.nature.com/articles/s41598-017-04982-1
2015
M Roukens G, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppänen V-M, Bos FL, et al.. Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain. Circ Res [Internet]. 2015;116(10):1660-1669. http://circres.ahajournals.org/content/116/10/1660.long
Dashkevich A, Raissadati A, Syrjälä SO, Zarkada G, Keränen MAI, Tuuminen R, et al.. Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts. American Journal of Transplantation [Internet]. 2015;16(4):1160-1172. http://onlinelibrary.wiley.com/doi/10.1111/ajt.13564/abstract
Dashkevich A, Raissadati A, Syrjälä SO, Zarkada G, Keränen MAI, Tuuminen R, et al.. Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts. American Journal of Transplantation [Internet]. 2015;16(4):1160-1172. http://onlinelibrary.wiley.com/doi/10.1111/ajt.13564/abstract
Saharinen P, Jeltsch M, Santoyo MM, Leppänen V-M, Alitalo K. The TIE Receptor Family. In: Wheeler DL, Yarden Y. Receptor Tyrosine Kinases: Family and Subfamilies [Internet]. Springer International Publishing; 2015. pp. 743-775. https://link.springer.com/content/pdf/10.1007%2F978-3-319-11888-8_16.pdf
2014
Jeltsch M, Jha SKumar, Tvorogov D, Anisimov A, Leppänen V-M, Holopainen T, et al.. CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation. Circulation [Internet]. 2014;129(19). http://circ.ahajournals.org/content/early/2014/02/19/CIRCULATIONAHA.113.002779.abstractPDF icon Postprint of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation (6.6 MB)PDF icon Postprint of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation (Suppl.) (2.38 MB)PDF icon Published version of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated... (incl. suppl.) (23.21 MB)
2013
Anisimov A, Leppänen V-M, Tvorogov D, Zarkada G, Jeltsch M, Holopainen T, et al.. The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Sci Signal. 2013;6(282):ra52. PDF icon Anisimov 2013 Science Signaling (1.92 MB)PDF icon Anisimov 2013 Science Signaling Supplement (2.09 MB)
Jeltsch M, Leppänen V-M, Saharinen P, Alitalo K. Receptor Tyrosine Kinase-Mediated Angiogenesis. Cold Spring Harbor Perspectives in Biology [Internet]. 2013;5(9). http://cshperspectives.cshlp.org/content/5/9/a009183PDF icon Jeltsch et al. (2013): Tyrosine Kinase-Mediated Angiogenesis. CSH Persp Biol (934.46 KB)
Leppänen V-M, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, et al.. Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2013;110(32):12960 - 12965. http://www.pnas.org/content/110/32/12960.long
Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, et al.. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development. 2013;140(7):1497-506. PDF icon Villefranc 2013 (7.86 MB)
Anisimov A, Tvorogov D, Alitalo A, Leppänen V-M, An Y, Han EC, et al.. Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation. 2013;127(4):424-434. PDF icon Anisimov 2013 (6.56 MB)PDF icon Anisimov 2013 Supplement (4.93 MB)
2012
Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, et al.. Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis. Am J Pathol. 2012;181(5):1607-20.
2011
Leppänen V-M, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, et al.. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood [Internet]. 2011;117(5):1507 - 15. http://view.ncbi.nlm.nih.gov/pubmed/21148085PDF icon Veli-Matti Leppänen & Michael Jeltsch et al., Blood 2011 (1.17 MB)PDF icon Veli-Matti Leppänen & Michael Jeltsch et al. Blood 2011, supplementary data (342.97 KB)
Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, et al.. VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease. Journal of Heart and Lung Transplantation. 2011;30:S118 - S118.
2010
Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, et al.. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev [Internet]. 2010;24(9):875 - 80. http://view.ncbi.nlm.nih.gov/pubmed/20439428PDF icon Pipsa Saharinen et al., Genes & Development 2010 (1.2 MB)PDF icon Pipsa Saharinen et al., Genes & Development 2010, supplement (9.15 MB)
Tvorogov D, Anisimov A, Zheng W, Leppänen V-M, Tammela T, Laurinavicius S, et al.. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell [Internet]. 2010;18(6):630 - 40. http://view.ncbi.nlm.nih.gov/pubmed/21130043PDF icon Denis Tvorogov et al., Cancer Cell 2010 (1.3 MB)PDF icon Denis Tvorogov et al., Cancer Cell 2010, supplement (828.69 KB)
Tvorogov D, Anisimov A, Zheng W, Leppänen V-M, Tammela T, Laurinavicius S, et al.. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell [Internet]. 2010;18(6):630 - 40. http://view.ncbi.nlm.nih.gov/pubmed/21130043PDF icon Denis Tvorogov et al., Cancer Cell 2010 (1.3 MB)PDF icon Denis Tvorogov et al., Cancer Cell 2010, supplement (828.69 KB)
Tvorogov D, Anisimov A, Zheng W, Leppänen V-M, Tammela T, Laurinavicius S, et al.. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell [Internet]. 2010;18(6):630 - 40. http://view.ncbi.nlm.nih.gov/pubmed/21130043PDF icon Denis Tvorogov et al., Cancer Cell 2010 (1.3 MB)PDF icon Denis Tvorogov et al., Cancer Cell 2010, supplement (828.69 KB)

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