<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Side Effects on Michael’s Domain</title><link>https://jeltsch.org/en/tags/side-effects/</link><description>Recent content in Side Effects on Michael’s Domain</description><generator>Hugo</generator><language>en-us</language><copyright>Copyright © 2002 - 2026 Michael Jeltsch.</copyright><lastBuildDate>Fri, 24 Jul 2026 00:18:18 +0300</lastBuildDate><atom:link href="https://jeltsch.org/en/tags/side-effects/index.xml" rel="self" type="application/rss+xml"/><item><title>Uncertainty about CRISPR's future</title><link>https://jeltsch.org/en/uncertainty_about_crispr_s_future/</link><pubDate>Sun, 18 Jun 2017 00:00:00 +0000</pubDate><guid>https://jeltsch.org/en/uncertainty_about_crispr_s_future/</guid><description>&lt;p&gt;Some feared, that the patent decisions on the CRISPR technology this spring might 
 &lt;a href="https://www.wired.com/2017/05/crispr-makes-clear-us-needs-biology-strategy-fast/" target="_blank" rel="noopener noreferrer nofollow"&gt;lead to a monopolization of the technology&amp;nbsp;






 
 
 
 &lt;svg class="svg-inline--fa fas fa-up-right-from-square fa-2xs" fill="currentColor" aria-hidden="true" role="img" viewBox="0 0 512 512" overflow="visible"&gt;&lt;use href="#fas-up-right-from-square"&gt;&lt;/use&gt;&lt;/svg&gt;&lt;/a&gt;
. However, according to a last month&amp;rsquo;s article in &lt;em&gt;Nature Methods&lt;/em&gt;, it is not at all clear at this moment, whether CRISPR will hit a home run for the editing of the human genome. If a single editing event is accompanied by hundreds of unwanted and unpredictable genomic changes, it would be difficult to argue in favor of it due to the unpredictability of the side effects. 
 &lt;a href="https://www.nature.com/nmeth/journal/v14/n6/full/nmeth.4293.html" target="_blank" rel="noopener noreferrer nofollow"&gt;This is just a single study in mice&amp;nbsp;






 
 
 
 &lt;svg class="svg-inline--fa fas fa-up-right-from-square fa-2xs" fill="currentColor" aria-hidden="true" role="img" viewBox="0 0 512 512" overflow="visible"&gt;&lt;use href="#fas-up-right-from-square"&gt;&lt;/use&gt;&lt;/svg&gt;&lt;/a&gt;
, but caution is warranted. The Nature Methods article is especially interesting, since the technology just had been 
 &lt;a href="https://www.nature.com/news/crispr-gene-editing-tested-in-a-person-for-the-first-time-1.20988?utm_source=MIT&amp;#43;TR&amp;#43;Newsletters&amp;amp;utm_campaign=bb7ed13a73-newsletters-the-download&amp;amp;utm_medium=email&amp;amp;utm_term=0_997ed6f472-bb7ed13a73-153692513&amp;amp;goal=0_997ed6f472-bb7ed13a73-153692513&amp;amp;mc_cid=bb7ed13a73&amp;amp;mc_eid=18013ac57b" target="_blank" rel="noopener noreferrer nofollow"&gt;used in humans for the first time&amp;nbsp;






 
 
 
 &lt;svg class="svg-inline--fa fas fa-up-right-from-square fa-2xs" fill="currentColor" aria-hidden="true" role="img" viewBox="0 0 512 512" overflow="visible"&gt;&lt;use href="#fas-up-right-from-square"&gt;&lt;/use&gt;&lt;/svg&gt;&lt;/a&gt;
.Even if the intellectual property is held by a single company, it is unclear, how a patent could be enforced. CRISPR differs from many other technologies by having a very low entry barrier in terms of cost and know-how. Almost every life science researcher could do it at home in their garages…&lt;/p&gt;</description></item></channel></rss>