<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Tip Cell Concept on Michael’s Domain</title><link>https://jeltsch.org/en/tags/tip-cell-concept/</link><description>Recent content in Tip Cell Concept on Michael’s Domain</description><generator>Hugo</generator><language>en-us</language><copyright>Copyright © 2002 - 2026 Michael Jeltsch.</copyright><lastBuildDate>Fri, 24 Jul 2026 00:18:18 +0300</lastBuildDate><atom:link href="https://jeltsch.org/en/tags/tip-cell-concept/index.xml" rel="self" type="application/rss+xml"/><item><title>1000+ citations</title><link>https://jeltsch.org/en/1000_citations/</link><pubDate>Wed, 15 May 2019 00:00:00 +0000</pubDate><guid>https://jeltsch.org/en/1000_citations/</guid><description>&lt;p&gt;The first among my publications to brake the 1000 citations-barrier was 
 &lt;a href="https://doi.org/10.1083/jcb.200302047" target="_blank" rel="noopener noreferrer nofollow"&gt;Gerhardt et al. 2003&amp;nbsp;






 
 
 
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. With the &amp;ldquo;tip cell concept&amp;rdquo;, it set a paradigm for vascular biology research: Not all endothelial cells are equal and the tip cell is a specialized cell that marks the forefront of the angiogenic sprout. However, my contribution was limited (number 7 out of 11 authors): I produced most of the proteins that were needed for the study. This spring, 
 &lt;a href="https://doi.org/10.1126/science.276.5317.1423" target="_blank" rel="noopener noreferrer nofollow"&gt;Jeltsch et al. 1997&amp;nbsp;






 
 
 
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 crossed the first time the 1000-citation mark. The paper describes a mouse, that overexpresses VEGF-C in the skin. It is the first ever in-vivo demonstration of a lymphangiogenic growth factor. Although not setting any paradigm, it marks the start of the 
 &lt;a href="https://web.archive.org/web/20160305010215/http://www.nature.com/focus/angiogenesis/classics/vegf.html" target="_blank" rel="noopener noreferrer nofollow"&gt;molecular era in lymphatic research&amp;nbsp;






 
 
 
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. What percentage of papers achieve 1000+ citations? That differs between disciplines, but e.g. according to 
 &lt;a href="https://en.wikipedia.org/wiki/Citation_impact" target="_blank" rel="noopener noreferrer nofollow"&gt;https://en.wikipedia.org/wiki/Citation_impact&amp;nbsp;






 
 
 
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 on average it is less than 1 in 4000. Compare this to the average paper, which receives 7.8 citations. And even this average is heavily influenced by a few highly-cited papers (
 &lt;a href="https://commons.wikimedia.org/wiki/File:Journal_impact_factor_Nature_Plos_One.png" target="_blank" rel="noopener noreferrer nofollow"&gt;similar to the Impact Factor&amp;nbsp;






 
 
 
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). The median number of citations is 4, meaning that about half of all papers have less than 4 citations (see 
 &lt;a href="http://www.scottbot.net/HIAL/index.html@p=22108.html" target="_blank" rel="noopener noreferrer nofollow"&gt;here&amp;nbsp;






 
 
 
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