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Submitted
Mavali-Zadeh A
,
Gatto E
,
Lettieri R
,
Bokharaie B
,
Caravella A
,
D'Ottavi C
, et al.
.
Biomass-derived Lignin Nanoparticles for the Sustained Delivery of Vascular Endothelial Growth Factor-C
. Molecular Pharmaceutics [Internet]. Submitted;.
https://doi.org/10.1101/2025.04.23.649697
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Preprint
(8.34 MB)
2025
Iqbal S
,
Andersson S
,
Nesta E
,
Pentinmikko N
,
Kumar A
,
Jha SK
, et al.
.
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
. Cell Stem Cell [Internet]. 2025;32(4):613 - 626.e8.
https://www.sciencedirect.com/science/article/pii/S1934590925000487
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2024
López-Cerdá S
,
Molinaro G
,
ParejaTello R
,
Correia A
,
Künig S
,
Steinberger P
, et al.
.
Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide and Serpine1 siRNA Lipid–Polymer Nanoparticles Targeting Macrophage Dysregulation in Tendinopathy
. ACS Applied Materials & Interfaces [Internet]. 2024;16(15):18643 - 18657.
https://pubs.acs.org/doi/10.1021/acsami.4c02363
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López-Cerdá et al. - 2024 - Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide [...]
(7.06 MB)
2023
Rauniyar K
,
Bokharaie H
,
Jeltsch M
.
Expansion and collapse of VEGF diversity in major clades of the animal kingdom
. Angiogenesis [Internet]. 2023;26(3):437 - 461.
https://link.springer.com/10.1007/s10456-023-09874-9
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Rauniyar et al. - 2023 - Expansion and collapse of VEGF diversity in major clades of the animal kingdom
(3.59 MB)
2021
Künnapuu J
,
Bokharaie H
,
Jeltsch M
.
Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs
. Biology [Internet]. 2021;10(2):167.
https://www.mdpi.com/2079-7737/10/2/167
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Künnapuu et al. - 2021 - Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential [...]
(3.44 MB)
2020
Mukenge S
,
Jha SK
,
Catena M
,
Manara E
,
Leppänen V‐M
,
Lenti E
, et al.
.
Investigation on the role of biallelic variants in VEGF‐C found in a patient affected by Milroy‐like lymphedema
. Molecular Genetics & Genomic Medicine [Internet]. 2020;00:e1389.
https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389
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Mukenge et al. 2020
(1.06 MB)
Mukenge S
,
Jha SK
,
Catena M
,
Manara E
,
Leppänen V‐M
,
Lenti E
, et al.
.
Investigation on the role of biallelic variants in VEGF‐C found in a patient affected by Milroy‐like lymphedema
. Molecular Genetics & Genomic Medicine [Internet]. 2020;00:e1389.
https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389
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Mukenge et al. 2020
(1.06 MB)
2017
Jha SK
,
Rauniyar K
,
Kärpänen T
,
Leppänen V-M
,
Brouillard P
,
Vikkula M
, et al.
.
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
. Scientific Reports [Internet]. 2017;7(1):4916.
https://www.nature.com/articles/s41598-017-04982-1
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2016
Batchu KC
,
Hänninen S
,
Jha SK
,
Jeltsch M
,
Somerharju P
.
Factors regulating the substrate specificity of cytosolic phospholipase A2-alpha in vitro
. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2016;1861(11):1597.
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Batchu et al. - 2016 - Factors regulating the substrate specificity of cy.pdf
(986.25 KB)
Johns SC
,
Yin X
,
Jeltsch M
,
Bishop JR
,
Schuksz M
,
Ghazal REl
, et al.
.
Functional Importance of a Proteoglycan Co-Receptor in Pathologic Lymphangiogenesis
. Circulation Research [Internet]. 2016;119(2):210-221.
http://circres.ahajournals.org/content/early/2016/05/25/CIRCRESAHA.116.308504
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Johns et al. 2016: Functional Importance of a Proteoglycan Co-Receptor in Pathologic Lymphangiogenesis
(3.69 MB)
Johns et al. 2016: Functional Importance of a Proteoglycan Co-Receptor in Pathologic Lymphangiogenesis: Supplemental Data
(3.3 MB)
2015
M Roukens G
,
Peterson-Maduro J
,
Padberg Y
,
Jeltsch M
,
Leppänen V-M
,
Bos FL
, et al.
.
Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.
Circ Res [Internet]. 2015;116(10):1660-1669.
http://circres.ahajournals.org/content/116/10/1660.long
PubMed
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Batchu KChaithanya
,
Hokynar K
,
Jeltsch M
,
Mattonet K
,
Somerharju P
.
Substrate efflux propensity is the key determinant of iPLA-β-mediated glycerophospholipid hydrolysised
. Journal of Biological Chemistry [Internet]. 2015;.
http://www.jbc.org/content/early/2015/02/23/jbc.M115.642835.abstract
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J. Biol. Chem.-2015-Batchu-jbc.M115.642835.pdf
(786.13 KB)
2013
Leppänen V-M
,
Tvorogov D
,
Kisko K
,
Prota AE
,
Jeltsch M
,
Anisimov A
, et al.
.
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2013;110(32):12960 - 12965.
http://www.pnas.org/content/110/32/12960.long
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Villefranc JA
,
Nicoli S
,
Bentley K
,
Jeltsch M
,
Zarkada G
,
Moore JC
, et al.
.
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.
Development. 2013;140(7):1497-506.
PubMed
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Villefranc 2013
(7.86 MB)
2011
Leppänen V-M
,
Jeltsch M
,
Anisimov A
,
Tvorogov D
,
Aho K
,
Kalkkinen N
, et al.
.
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity
. Blood [Internet]. 2011;117(5):1507 - 15.
http://view.ncbi.nlm.nih.gov/pubmed/21148085
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Veli-Matti Leppänen & Michael Jeltsch et al., Blood 2011
(1.17 MB)
Veli-Matti Leppänen & Michael Jeltsch et al. Blood 2011, supplementary data
(342.97 KB)
2010
Leppänen V-M
,
Prota AE
,
Jeltsch M
,
Anisimov A
,
Kalkkinen N
,
Strandin T
, et al.
.
Structural determinants of growth factor binding and specificity by VEGF receptor 2
. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2010;107(6):2425 - 30.
http://view.ncbi.nlm.nih.gov/pubmed/20145116
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Veli-Matti Leppänen et al. PNAS 2010
(1 MB)
Veli-Matti Leppänen et al. PNAS 2010, supporting information
(2.23 MB)
Bry M
,
Kivelä R
,
Holopainen T
,
Anisimov A
,
Tammela T
,
Soronen J
, et al.
.
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
. Circulation [Internet]. 2010;122(17):1725 - 33.
http://view.ncbi.nlm.nih.gov/pubmed/20937974
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Maija Bry et al., Circulation 2010
(2.23 MB)
Maija Bry et al., Circulation 2010, supplement
(17.77 MB)
2008
Karpanen T
,
Bry M
,
Ollila HM
,
Seppänen-Laakso T
,
Liimatta E
,
Leskinen H
, et al.
.
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
. Circ Res [Internet]. 2008;103(9):1018 - 26.
http://view.ncbi.nlm.nih.gov/pubmed/18757827
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Terhi Kärpänen et al., Circulation Research 2008
(898.27 KB)
Terhi Kärpänen et al., Circulation Research 2008, supplement
(1.56 MB)
Li X
,
Tjwa M
,
Van Hove I
,
Enholm B
,
Neven E
,
Paavonen K
, et al.
.
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
. Arterioscler Thromb Vasc Biol [Internet]. 2008;28(9):1614 - 20.
http://view.ncbi.nlm.nih.gov/pubmed/18511699
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Xuri Li et al., Arteriosclerosis, Thrombosis, and Vascular Biology 2008
(738.26 KB)
Xuri Li et al., Arteriosclerosis, Thrombosis, and Vascular Biology 2008, data supplement
(1012.6 KB)
2005
Baluk P
,
Tammela T
,
Ator E
,
Lyubynska N
,
Achen MG
,
Hicklin DJ
, et al.
.
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
. J Clin Invest [Internet]. 2005;115(2):247 - 57.
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Peter Baluk et al., Journal of Clinical Investigation 2005
(1.89 MB)
2004
Karkkainen MJ
,
Haiko P
,
Sainio K
,
Partanen J
,
Taipale J
,
Petrova TV
, et al.
.
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
. Nat Immunol [Internet]. 2004;5(1):74 - 80.
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Marika Kärkkäinen et al., Nature Immunology 2004
(3.01 MB)
Marika Kärkkäinen et al., Nature Immunology 2004, supplementary data 1
(1.27 MB)
Marika Kärkkäinen et al., Nature Immunology 2004, supplementary data 2
(1.23 MB)
2003
Gerhardt H
,
Golding M
,
Fruttiger M
,
Ruhrberg C
,
Lundkvist A
,
Abramsson A
, et al.
.
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
. J Cell Biol [Internet]. 2003;161(6):1163 - 77.
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Holger Gerhardt et al., The Journal of Biological Chemistry 2003
(2.24 MB)
2002
Saaristo A
,
Veikkola T
,
Enholm B
,
Hytönen M
,
Arola J
,
Pajusola K
, et al.
.
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
. FASEB J [Internet]. 2002;16(9):1041 - 9.
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Anne Saaristo et al., FASEB Journal 2002
(966.08 KB)
2001
Mandriota SJ
,
Jussila L
,
Jeltsch M
,
Compagni A
,
Baetens D
,
Prevo R
, et al.
.
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
. EMBO J [Internet]. 2001;20(4):672 - 82.
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Stefano Mandriota et al., EMBO Journal 2001
(736.96 KB)
Mandriota SJ
,
Jussila L
,
Jeltsch M
,
Compagni A
,
Baetens D
,
Prevo R
, et al.
.
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
. EMBO J [Internet]. 2001;20(4):672 - 82.
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Stefano Mandriota et al., EMBO Journal 2001
(736.96 KB)
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