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Mavali-Zadeh A
,
Gatto E
,
Lettieri R
,
Bokharaie B
,
Caravella A
,
D'Ottavi C
, et al.
.
Biomass-derived Lignin Nanoparticles for the Sustained Delivery of Vascular Endothelial Growth Factor-C
. Molecular Pharmaceutics [Internet]. Submitted;.
https://doi.org/10.1101/2025.04.23.649697
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Preprint
(8.34 MB)
Mavali-Zadeh A
,
Gatto E
,
Lettieri R
,
Bokharaie B
,
Caravella A
,
D'Ottavi C
, et al.
.
Biomass-derived Lignin Nanoparticles for the Sustained Delivery of Vascular Endothelial Growth Factor-C
. Molecular Pharmaceutics [Internet]. Submitted;.
https://doi.org/10.1101/2025.04.23.649697
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Preprint
(8.34 MB)
2025
Iqbal S
,
Andersson S
,
Nesta E
,
Pentinmikko N
,
Kumar A
,
Jha SK
, et al.
.
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
. Cell Stem Cell [Internet]. 2025;32(4):613 - 626.e8.
https://www.sciencedirect.com/science/article/pii/S1934590925000487
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2024
López-Cerdá S
,
Molinaro G
,
ParejaTello R
,
Correia A
,
Künig S
,
Steinberger P
, et al.
.
Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide and Serpine1 siRNA Lipid–Polymer Nanoparticles Targeting Macrophage Dysregulation in Tendinopathy
. ACS Applied Materials & Interfaces [Internet]. 2024;16(15):18643 - 18657.
https://pubs.acs.org/doi/10.1021/acsami.4c02363
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López-Cerdá et al. - 2024 - Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide [...]
(7.06 MB)
2020
Mukenge S
,
Jha SK
,
Catena M
,
Manara E
,
Leppänen V‐M
,
Lenti E
, et al.
.
Investigation on the role of biallelic variants in VEGF‐C found in a patient affected by Milroy‐like lymphedema
. Molecular Genetics & Genomic Medicine [Internet]. 2020;00:e1389.
https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389
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Mukenge et al. 2020
(1.06 MB)
Mukenge S
,
Jha SK
,
Catena M
,
Manara E
,
Leppänen V‐M
,
Lenti E
, et al.
.
Investigation on the role of biallelic variants in VEGF‐C found in a patient affected by Milroy‐like lymphedema
. Molecular Genetics & Genomic Medicine [Internet]. 2020;00:e1389.
https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.1389
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Mukenge et al. 2020
(1.06 MB)
Gucciardo E
,
Lehti TA
,
Korhonen A
,
Salvén P
,
Lehti K
,
Jeltsch M
, et al.
.
Lymphatics and the eye. [Finnish]
. Duodecim Lääketieteellinen Aikakauskirja [Internet]. 2020;136(16):1777-1788.
https://www.duodecimlehti.fi/lehti/2020/16/duo15739
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Gucciardo et al. Lymphatics and the Eye (English version).
(3.31 MB)
Gucciardo E
,
Lehti TA
,
Korhonen A
,
Salvén P
,
Lehti K
,
Jeltsch M
, et al.
.
Lymphatics and the eye. [Finnish]
. Duodecim Lääketieteellinen Aikakauskirja [Internet]. 2020;136(16):1777-1788.
https://www.duodecimlehti.fi/lehti/2020/16/duo15739
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Gucciardo et al. Lymphatics and the Eye (English version).
(3.31 MB)
Gucciardo E
,
Lehti TA
,
Korhonen A
,
Salvén P
,
Lehti K
,
Jeltsch M
, et al.
.
Lymphatics and the eye. [Finnish]
. Duodecim Lääketieteellinen Aikakauskirja [Internet]. 2020;136(16):1777-1788.
https://www.duodecimlehti.fi/lehti/2020/16/duo15739
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Gucciardo et al. Lymphatics and the Eye (English version).
(3.31 MB)
Fang S
,
Chen S
,
Nurmi H
,
Leppänen V-M
,
Jeltsch M
,
Scadden DT
, et al.
.
VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche
. Blood [Internet]. 2020;:accepted - for publication.
https://ashpublications.org/blood/article/doi/10.1182/blood.2020005699/463465/VEGF-C-Protects-the-Integrity-of-Bone-Marrow
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Fang et al. 2020 - VEGF-C protects the integrity of bone marrow perivascular niche
(6 MB)
2019
Lackner M
,
Schmotz C
,
Jeltsch M
.
The Proteolytic Activation of Vascular Endothelial Growth Factor-C
. Lymphologie in Forschung und Praxis [Internet]. 2019;23(2):88 - 98.
https://doi.org/10.5281/zenodo.3629263
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English version: Lackner et al. 2019
(2.94 MB)
German version: Lackner et al. 2019
(673.37 KB)
2017
Jha SK
,
Rauniyar K
,
Kärpänen T
,
Leppänen V-M
,
Brouillard P
,
Vikkula M
, et al.
.
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
. Scientific Reports [Internet]. 2017;7(1):4916.
https://www.nature.com/articles/s41598-017-04982-1
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2015
M Roukens G
,
Peterson-Maduro J
,
Padberg Y
,
Jeltsch M
,
Leppänen V-M
,
Bos FL
, et al.
.
Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.
Circ Res [Internet]. 2015;116(10):1660-1669.
http://circres.ahajournals.org/content/116/10/1660.long
PubMed
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Dashkevich A
,
Raissadati A
,
Syrjälä SO
,
Zarkada G
,
Keränen MAI
,
Tuuminen R
, et al.
.
Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts
. American Journal of Transplantation [Internet]. 2015;16(4):1160-1172.
http://onlinelibrary.wiley.com/doi/10.1111/ajt.13564/abstract
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Dashkevich A
,
Raissadati A
,
Syrjälä SO
,
Zarkada G
,
Keränen MAI
,
Tuuminen R
, et al.
.
Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts
. American Journal of Transplantation [Internet]. 2015;16(4):1160-1172.
http://onlinelibrary.wiley.com/doi/10.1111/ajt.13564/abstract
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Saharinen P
,
Jeltsch M
,
Santoyo MM
,
Leppänen V-M
,
Alitalo K
.
The TIE Receptor Family
. In:
Wheeler DL
,
Yarden Y
. Receptor Tyrosine Kinases: Family and Subfamilies [Internet]. Springer International Publishing; 2015. pp. 743-775.
https://link.springer.com/content/pdf/10.1007%2F978-3-319-11888-8_16.pdf
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2014
Jeltsch M
,
Jha SKumar
,
Tvorogov D
,
Anisimov A
,
Leppänen V-M
,
Holopainen T
, et al.
.
CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation
. Circulation [Internet]. 2014;129(19).
http://circ.ahajournals.org/content/early/2014/02/19/CIRCULATIONAHA.113.002779.abstract
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Postprint of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation
(6.6 MB)
Postprint of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation (Suppl.)
(2.38 MB)
Published version of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated... (incl. suppl.)
(23.21 MB)
2013
Anisimov A
,
Leppänen V-M
,
Tvorogov D
,
Zarkada G
,
Jeltsch M
,
Holopainen T
, et al.
.
The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands
. Sci Signal. 2013;6(282):ra52.
PubMed
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Anisimov 2013 Science Signaling
(1.92 MB)
Anisimov 2013 Science Signaling Supplement
(2.09 MB)
Jeltsch M
,
Leppänen V-M
,
Saharinen P
,
Alitalo K
.
Receptor Tyrosine Kinase-Mediated Angiogenesis
. Cold Spring Harbor Perspectives in Biology [Internet]. 2013;5(9).
http://cshperspectives.cshlp.org/content/5/9/a009183
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Jeltsch et al. (2013): Tyrosine Kinase-Mediated Angiogenesis. CSH Persp Biol
(934.46 KB)
Leppänen V-M
,
Tvorogov D
,
Kisko K
,
Prota AE
,
Jeltsch M
,
Anisimov A
, et al.
.
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2013;110(32):12960 - 12965.
http://www.pnas.org/content/110/32/12960.long
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Villefranc JA
,
Nicoli S
,
Bentley K
,
Jeltsch M
,
Zarkada G
,
Moore JC
, et al.
.
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.
Development. 2013;140(7):1497-506.
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Villefranc 2013
(7.86 MB)
Anisimov A
,
Tvorogov D
,
Alitalo A
,
Leppänen V-M
,
An Y
,
Han EC
, et al.
.
Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis
. Circulation. 2013;127(4):424-434.
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Anisimov 2013
(6.56 MB)
Anisimov 2013 Supplement
(4.93 MB)
2012
Krebs R
,
Tikkanen JM
,
Ropponen JO
,
Jeltsch M
,
Jokinen JJ
,
Ylä-Herttuala S
, et al.
.
Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis.
Am J Pathol. 2012;181(5):1607-20.
PubMed
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2011
Leppänen V-M
,
Jeltsch M
,
Anisimov A
,
Tvorogov D
,
Aho K
,
Kalkkinen N
, et al.
.
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity
. Blood [Internet]. 2011;117(5):1507 - 15.
http://view.ncbi.nlm.nih.gov/pubmed/21148085
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Veli-Matti Leppänen & Michael Jeltsch et al., Blood 2011
(1.17 MB)
Veli-Matti Leppänen & Michael Jeltsch et al. Blood 2011, supplementary data
(342.97 KB)
Krebs R
,
Tikkanen JM
,
Ropponen JO
,
Jeltsch M
,
Jokinen JJ
,
Ylä-Herttuala S
, et al.
.
VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease
. Journal of Heart and Lung Transplantation. 2011;30:S118 - S118.
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