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2006
Jeltsch M
,
Karpanen T
,
Strandin T
,
Aho K
,
Lankinen H
,
Alitalo K
.
Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns
. J Biol Chem [Internet]. 2006;281(17):12187 - 95.
http://view.ncbi.nlm.nih.gov/pubmed/16505489
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Michael Jeltsch et al., The Journal of Biological Chemistry 2006
(1.04 MB)
Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 1
(1.01 MB)
Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 2
(596.06 KB)
Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 3
(738.98 KB)
Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 4
(710.03 KB)
Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 5
(163.64 KB)
Jeltsch M
,
Alitalo K
.
VEGF Receptors
. In Sigma-RBI Handbook of Receptor Classification and Signal Transduction [Internet]. 5.th ed. Sigma; 2006.
http://www.sigmaaldrich.com/technical-documents/articles/biology/rbi-handbook.html
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Sigma-RBI Handbook of Receptor Classification and Signal Transduction: VEGF Receptors
(263.92 KB)
2007
Tammela T
,
He Y
,
Lyytikkä J
,
Jeltsch M
,
Markkanen J
,
Pajusola K
, et al.
.
Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins
. Circ Res [Internet]. 2007;100(10):1468 - 75.
http://view.ncbi.nlm.nih.gov/pubmed/17478733
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Tuomas Tammela et al., Circulation Research 2007
(1.1 MB)
Keskitalo S
,
Tammela T
,
Lyytikka J
,
Karpanen T
,
Jeltsch M
,
Markkanen J
, et al.
.
Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein
. Circ Res [Internet]. 2007;100(10):1460 - 7.
http://view.ncbi.nlm.nih.gov/pubmed/17478734
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Salla Keskitalo et al., Circulation Research 2007
(1.98 MB)
Heckman CA
,
Holopainen T
,
Wirzenius M
,
Keskitalo S
,
Jeltsch M
,
Wedge SR
, et al.
.
Inhibiton of VEGF-C-induced VEGFR-3 activity and lymphatic endothelial cell function by the tyrosine kinase inhibitor AZD2171
. In 98th Annual Meeting of the American-Association-for-Cancer-Research [Internet]. Los Angeles, CA: American Association for Cancer Research; 2007.
http://dx.doi.org/10.1158/0008-5472.CAN-07-5809
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Heckman et al. - 2007 - Inhibiton of VEGF-C-induced VEGFR-3 activity and l.pdf
(236.37 KB)
2008
Karpanen T
,
Bry M
,
Ollila HM
,
Seppänen-Laakso T
,
Liimatta E
,
Leskinen H
, et al.
.
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
. Circ Res [Internet]. 2008;103(9):1018 - 26.
http://view.ncbi.nlm.nih.gov/pubmed/18757827
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Terhi Kärpänen et al., Circulation Research 2008
(898.27 KB)
Terhi Kärpänen et al., Circulation Research 2008, supplement
(1.56 MB)
Li X
,
Tjwa M
,
Van Hove I
,
Enholm B
,
Neven E
,
Paavonen K
, et al.
.
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
. Arterioscler Thromb Vasc Biol [Internet]. 2008;28(9):1614 - 20.
http://view.ncbi.nlm.nih.gov/pubmed/18511699
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Xuri Li et al., Arteriosclerosis, Thrombosis, and Vascular Biology 2008
(738.26 KB)
Xuri Li et al., Arteriosclerosis, Thrombosis, and Vascular Biology 2008, data supplement
(1012.6 KB)
Heckman CA
,
Holopainen T
,
Wirzenius M
,
Keskitalo S
,
Jeltsch M
,
Ylä-Herttuala S
, et al.
.
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
. Cancer Res [Internet]. 2008;68(12):4754 - 62.
http://view.ncbi.nlm.nih.gov/pubmed/18559522
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Caroline Heckman et al., Cancer Research 2008
(504.8 KB)
2009
Anisimov A
,
Alitalo A
,
Korpisalo P
,
Soronen J
,
Kaijalainen S
,
Leppänen V-M
, et al.
.
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle
. Circ Res [Internet]. 2009;104(11):1302 - 12.
http://view.ncbi.nlm.nih.gov/pubmed/19443835
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Andrey Anisimov et al., Circulation Research 2009
(8.03 MB)
Andrey Anisimov et al., Circulation Research 2009, supplement
(5.9 MB)
2010
Saharinen P
,
Helotera H
,
Miettinen J
,
Norrmen C
,
D'Amico G
,
Jeltsch M
, et al.
.
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
. Genes Dev [Internet]. 2010;24(9):875 - 80.
http://view.ncbi.nlm.nih.gov/pubmed/20439428
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Pipsa Saharinen et al., Genes & Development 2010
(1.2 MB)
Pipsa Saharinen et al., Genes & Development 2010, supplement
(9.15 MB)
Tvorogov D
,
Anisimov A
,
Zheng W
,
Leppänen V-M
,
Tammela T
,
Laurinavicius S
, et al.
.
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization
. Cancer Cell [Internet]. 2010;18(6):630 - 40.
http://view.ncbi.nlm.nih.gov/pubmed/21130043
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Denis Tvorogov et al., Cancer Cell 2010
(1.3 MB)
Denis Tvorogov et al., Cancer Cell 2010, supplement
(828.69 KB)
Leppänen V-M
,
Prota AE
,
Jeltsch M
,
Anisimov A
,
Kalkkinen N
,
Strandin T
, et al.
.
Structural determinants of growth factor binding and specificity by VEGF receptor 2
. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2010;107(6):2425 - 30.
http://view.ncbi.nlm.nih.gov/pubmed/20145116
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Veli-Matti Leppänen et al. PNAS 2010
(1 MB)
Veli-Matti Leppänen et al. PNAS 2010, supporting information
(2.23 MB)
Albrecht I
,
Kopfstein L
,
Strittmatter K
,
Schomber T
,
Falkevall A
,
Hagberg CE
, et al.
.
Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis
. PLoS ONE [Internet]. 2010;5(11):e14109.
http://view.ncbi.nlm.nih.gov/pubmed/21124841
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Imke Albrecht et al., PLoS One 2010
(3.37 MB)
Bry M
,
Kivelä R
,
Holopainen T
,
Anisimov A
,
Tammela T
,
Soronen J
, et al.
.
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
. Circulation [Internet]. 2010;122(17):1725 - 33.
http://view.ncbi.nlm.nih.gov/pubmed/20937974
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Maija Bry et al., Circulation 2010
(2.23 MB)
Maija Bry et al., Circulation 2010, supplement
(17.77 MB)
2011
Leppänen V-M
,
Jeltsch M
,
Anisimov A
,
Tvorogov D
,
Aho K
,
Kalkkinen N
, et al.
.
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity
. Blood [Internet]. 2011;117(5):1507 - 15.
http://view.ncbi.nlm.nih.gov/pubmed/21148085
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Veli-Matti Leppänen & Michael Jeltsch et al., Blood 2011
(1.17 MB)
Veli-Matti Leppänen & Michael Jeltsch et al. Blood 2011, supplementary data
(342.97 KB)
Krebs R
,
Tikkanen JM
,
Ropponen JO
,
Jeltsch M
,
Jokinen JJ
,
Ylä-Herttuala S
, et al.
.
VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease
. Journal of Heart and Lung Transplantation. 2011;30:S118 - S118.
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2012
Krebs R
,
Tikkanen JM
,
Ropponen JO
,
Jeltsch M
,
Jokinen JJ
,
Ylä-Herttuala S
, et al.
.
Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis.
Am J Pathol. 2012;181(5):1607-20.
PubMed
DOI
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2013
Anisimov A
,
Leppänen V-M
,
Tvorogov D
,
Zarkada G
,
Jeltsch M
,
Holopainen T
, et al.
.
The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands
. Sci Signal. 2013;6(282):ra52.
PubMed
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Anisimov 2013 Science Signaling
(1.92 MB)
Anisimov 2013 Science Signaling Supplement
(2.09 MB)
Krebs R
,
Jeltsch M
.
Die lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in diseases of the lymphatic system. [bilingual: English, German].
Lymphologie in Forschung und Praxis [Internet]. 2013;17(2):96 - 104.
http://jeltsch.org/sites/jeltsch.org/files/JeltschMichael_Lymphforsch2013_96.pdf
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Krebs & Jeltsch (2013): The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in diseas...
(3.88 MB)
Krebs & Jeltsch (2013): Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D. Teil 2. Die Rolle von VEGF-C und VEGF-D bei ...
(2.6 MB)
Krebs R
,
Jeltsch M
.
The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Basic principles and embryonic development. [bilingual: English, German].
Lymphologie in Forschung und Praxis [Internet]. 2013;17(1):30 - 37.
http://jeltsch.org/sites/jeltsch.org/files/JeltschMichael_Lymphforsch2013_30.pdf
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Krebs & Jeltsch (2013): The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Fundamentals and embryonic development.
(2.08 MB)
Krebs & Jeltsch (2013): Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D. Teil 1. Grundlagen und Embryonalentwicklung.
(1.82 MB)
Jeltsch M
,
Leppänen V-M
,
Saharinen P
,
Alitalo K
.
Receptor Tyrosine Kinase-Mediated Angiogenesis
. Cold Spring Harbor Perspectives in Biology [Internet]. 2013;5(9).
http://cshperspectives.cshlp.org/content/5/9/a009183
DOI
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Jeltsch et al. (2013): Tyrosine Kinase-Mediated Angiogenesis. CSH Persp Biol
(934.46 KB)
Leppänen V-M
,
Tvorogov D
,
Kisko K
,
Prota AE
,
Jeltsch M
,
Anisimov A
, et al.
.
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2013;110(32):12960 - 12965.
http://www.pnas.org/content/110/32/12960.long
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Villefranc JA
,
Nicoli S
,
Bentley K
,
Jeltsch M
,
Zarkada G
,
Moore JC
, et al.
.
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.
Development. 2013;140(7):1497-506.
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Villefranc 2013
(7.86 MB)
Anisimov A
,
Tvorogov D
,
Alitalo A
,
Leppänen V-M
,
An Y
,
Han EC
, et al.
.
Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis
. Circulation. 2013;127(4):424-434.
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Anisimov 2013
(6.56 MB)
Anisimov 2013 Supplement
(4.93 MB)
2014
Jeltsch M
,
Jha SKumar
,
Tvorogov D
,
Anisimov A
,
Leppänen V-M
,
Holopainen T
, et al.
.
CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation
. Circulation [Internet]. 2014;129(19).
http://circ.ahajournals.org/content/early/2014/02/19/CIRCULATIONAHA.113.002779.abstract
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Postprint of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation
(6.6 MB)
Postprint of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated VEGF-C activation (Suppl.)
(2.38 MB)
Published version of Jeltsch et al. 2014 (Circulation): CCBE1 enhances lymphangiogenesis via ADAMTS3-mediated... (incl. suppl.)
(23.21 MB)
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