VEGF-C/VEGFR-2 complex structure took 13 years to solve

Last modified on July 24, 2026 • 1 min read • 76 words
Finally our paper was accepted for publication in PNAS (downloadable also from here).
VEGF-C/VEGFR-2 complex structure took 13 years to solve
Image by Kari Alitalo
Finally our paper was accepted for publication in PNAS  (downloadable also from here ). I started the project by making the first construct 13 years ago, but it went nowhere for the first 9 years due to insufficient concentration of efforts and a few unlucky choices in the experimental design. I opted for bacterial protein first, but although the refolding worked, it was very inefficient (Ala mutation and a smart trimming of N- and C-terminus. More…