Biblio

Journal Article
Veikkola T, Jussila L, Makinen T, Karpanen T, Jeltsch M, Petrova TV, et al.. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J [Internet]. 2001;20(6):1223 - 31. http://view.ncbi.nlm.nih.gov/pubmed/11250889PDF ikon Tanja Veikkola et al., EMBO Journal 2001 (491.14 KB)
Leppänen V-M, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, et al.. Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2010;107(6):2425 - 30. http://view.ncbi.nlm.nih.gov/pubmed/20145116PDF ikon Veli-Matti Leppänen et al. PNAS 2010 (1 MB)PDF ikon Veli-Matti Leppänen et al. PNAS 2010, supporting information (2.23 MB)
Leppänen V-M, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, et al.. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood [Internet]. 2011;117(5):1507 - 15. http://view.ncbi.nlm.nih.gov/pubmed/21148085PDF ikon Veli-Matti Leppänen & Michael Jeltsch et al., Blood 2011 (1.17 MB)PDF ikon Veli-Matti Leppänen & Michael Jeltsch et al. Blood 2011, supplementary data (342.97 KB)
Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg CE, et al.. Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS ONE [Internet]. 2010;5(11):e14109. http://view.ncbi.nlm.nih.gov/pubmed/21124841PDF ikon Imke Albrecht et al., PLoS One 2010 (3.37 MB)
Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, et al.. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res [Internet]. 2008;68(12):4754 - 62. http://view.ncbi.nlm.nih.gov/pubmed/18559522PDF ikon Caroline Heckman et al., Cancer Research 2008 (504.8 KB)
He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, et al.. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res [Internet]. 2005;65(11):4739 - 46. http://view.ncbi.nlm.nih.gov/pubmed/15930292PDF ikon Yulong He et al., Cancer Research 2005 (1.82 MB)
Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, et al.. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci U S A [Internet]. 1998;95(20):11709 - 14. http://view.ncbi.nlm.nih.gov/pubmed/9751730PDF ikon Birgitta Olofsson et al., PNAS 1998 (470.59 KB)
Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, et al.. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol [Internet]. 2004;5(1):74 - 80. http://view.ncbi.nlm.nih.gov/pubmed/14634646PDF ikon Marika Kärkkäinen et al., Nature Immunology 2004 (3.01 MB)PDF ikon Marika Kärkkäinen et al., Nature Immunology 2004, supplementary data 1 (1.27 MB)PDF ikon Marika Kärkkäinen et al., Nature Immunology 2004, supplementary data 2 (1.23 MB)
Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, et al.. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci U S A [Internet]. 1998;95(2):548 - 53. http://view.ncbi.nlm.nih.gov/pubmed/9435229PDF ikon Marc Achen et al., PNAS 1998 (447.59 KB)
Pepper MS, Mandriota SJ, Jeltsch M, Kumar V, Alitalo K. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. J Cell Physiol [Internet]. 1998;177(3):439 - 52. http://view.ncbi.nlm.nih.gov/pubmed/9808152PDF ikon Michael Pepper et al., Journal of Cellular Physiology 1998 (689.97 KB)
Jeltsch M, Karpanen T, Strandin T, Aho K, Lankinen H, Alitalo K. Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns. J Biol Chem [Internet]. 2006;281(17):12187 - 95. http://view.ncbi.nlm.nih.gov/pubmed/16505489PDF ikon Michael Jeltsch et al., The Journal of Biological Chemistry 2006 (1.04 MB)PDF ikon Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 1 (1.01 MB)PDF ikon Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 2 (596.06 KB)PDF ikon Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 3 (738.98 KB)PDF ikon Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 4 (710.03 KB)PDF ikon Michael Jeltsch et al., The Journal of Biological Chemistry 2006, supplemental data 5 (163.64 KB)
Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, et al.. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation [Internet]. 2010;122(17):1725 - 33. http://view.ncbi.nlm.nih.gov/pubmed/20937974PDF ikon Maija Bry et al., Circulation 2010 (2.23 MB)PDF ikon Maija Bry et al., Circulation 2010, supplement (17.77 MB)
Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R, et al.. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J [Internet]. 2001;20(4):672 - 82. http://view.ncbi.nlm.nih.gov/pubmed/11179212PDF ikon Stefano Mandriota et al., EMBO Journal 2001 (736.96 KB)
Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, et al.. Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol [Internet]. 1997;173(2):211 - 5. http://view.ncbi.nlm.nih.gov/pubmed/9365524PDF ikon Vladimir Joukov et al., Journal of Cellular Physiology 1997 (127.57 KB)
Oh SJ, Jeltsch MM, Birkenhäger R, McCarthy JE, Weich HA, Christ B, et al.. VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Dev Biol [Internet]. 1997;188(1):96 - 109. http://view.ncbi.nlm.nih.gov/pubmed/9245515PDF ikon Su-Ja Oh et al., Developmental Biology 1997 (3.28 MB)
Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al.. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol [Internet]. 2003;161(6):1163 - 77. http://view.ncbi.nlm.nih.gov/pubmed/12810700PDF ikon Holger Gerhardt et al., The Journal of Biological Chemistry 2003 (2.24 MB)
Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V, et al.. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development [Internet]. 1996;122(12):3829 - 37. http://view.ncbi.nlm.nih.gov/pubmed/9012504PDF ikon Eola Kukk et al., Development 1996 (805.94 KB)
Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, et al.. VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease. Journal of Heart and Lung Transplantation. 2011;30:S118 - S118.
Thesis
Jeltsch M. VEGFR-3 Ligands and Lymphangiogenesis [Internet]. University of Helsinki. 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/jeltschPDF ikon Michael Jeltsch, PhD Thesis, 2002 (1.75 MB)

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