Today I installed the Staden Package on Tanja's Macintosh G4 computer (MacOS 10.3). I recommend using the ebiotools package made by Anders Nister. It includes other useful software such as EMBOSS, Blast, etc.). Installation instructions are available in the embnet news issues 9/1, 9/2, 9/3 and 10/1 or gathered into one pdf file from here. The installer puts all the stuff into the newly created /usr/ebiotools directory. I took a shell script that I had been writing for Linux and modified it to suit MacOSX. Here is the first version of the script and the configuration file for pregap4, which should be put into /usr/ebiotools/staden/userdata. The main problem is that you cannot associate file types with shell scripts in MacOSX (at least I don't know how). But there is a handy work-around this problem: Platypus: it wraps shell scripts (and several other scripts) into Cocoa. After that you still have to teach MacOSX that files with specific file endings (such as .ab1 in our case) should be handled with the shell script wrapper. Select the file, apple+i, open with, change recommended applications into all applications, navigate to and select the wrapper that was created by platypus and check the box labeled "always open files with this application". That's it. Unfortunately I didn't find a way to teach MacOSX permanently to open *.ab1 files with the shell script wrapper. When I click the "Apply to all other files of this type" button, I get an error message... ok, I might manage to sort this one out sooner or later.